What factors does the formation of diabetic nephropathy?

Diabetic nephropathy is one of the many complications of diabetes in which the main symptom is the emergence of glomeruli in the kidney, and prone to deteriorate. Once such symptoms would be late. So what are the factors of diabetic nephropathy forming it? Here introduce the factor of diabetic nephropathy:
First, genetic factors
Most people with diabetes, kidney disease patients eventually will not happen, but some long-term good glycemic control in patients with diabetic nephropathy also can occur, the main reason is the formation of the major glucose transporter in mesangial cells.
Second, high blood factors
Most of diabetic nephropathy and high blood sugar have a close relationship, when the patient's body in poor glycemic control, high blood sugar and glycation Light products after causing increased mesangial cell proliferation, extracellular matrix increased mesangial expansion, glomerular basement membrane thickening, thus contributing to the occurrence of diabetic nephropathy.
Third, hypertension factor
Hypertension and diabetic nephropathy although no direct relationship, but after the original blood pressure, high blood pressure during the course of elevated microalbuminuria can accelerate the deterioration of renal function in diabetic nephropathy patients, and induce diabetic nephropathy.
Fourth, renal hemodynamic abnormalities factor
Renal blood flow is the key factors play a role in the occurrence of diabetic nephropathy, even in the likely start of factors. Generally do a detailed analysis of the following four conditions:
1, when high blood sugar, increased pressure capillary wall, promote the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells detached from the basement membrane, resulting in glomerular perfusion was high, reverse osmosis process state.
2, the glomerular basement membrane collagen Ⅳ messenger nucleic acid increased sugar to make the basement membrane thickening, and ultimately the formation of diffuse mesangial, nodular lesions, which occurred glomerulosclerosis.
3, in the case of increased pressure in renal blood flow, increased protein filtration and promote growth of the matrix to form the glomerular basement membrane and mesangial resulting nodular glomerulosclerosis.