What factors led to symptoms of diabetic nephropathy

Many diabetic patients are concerned about their disease develop diabetic nephropathy, although the pathogenesis of diabetic nephropathy is not yet fully clear, but it is certain that not every patient with diabetes will occur diabetic nephropathy, now known to have three kinds of risk factors.
1 renal hemodynamic abnormalities
Renal hemodynamic abnormalities plays a vital role in diabetic nephropathy, and there may be the initiating factor of the disease. In addition, diabetic patients with hypertension will cause hemodynamic abnormalities, thus significantly speeding up the development and progression of diabetic nephropathy.
2 glycation end product formation
Sustained increases in blood sugar in patients with glycated end products of the production increase, thereby causing Ⅳ collagen,vitreous binding extracellular matrix protein changes, which will affect the structure and function of the kidney changes, manifested as endothelial cells, mesangial cells and smooth muscle cell proliferation, and ultimately lead to diabetic nephropathy.
3 genetic factors
Genetic cause increase the incidence of diabetic nephropathy. The study found that patients with diabetes also have a family history of essential hypertension occurred significantly increased risk of kidney disease can be three times higher than normal, the results suggest that the incidence of diabetic nephropathy familial aggregation phenomenon. However, some sick with diabetes for a long time has not developed as diabetic nephropathy, which also prompted a certain genetic relationship with diabetic nephropathy.
  Above it for you a brief look at the causes of diabetic nephropathy, and I hope you have some help, if you want to know more information, you can leave a message to chinakidneyhospital@gmail.com, we get back to you as soon as possible.