Diabetic nephropathy is a common complication of diabetes, the incidence of up to 47.66%, the main reason is the death of type 1 diabetes. Since the onset of type 1 diabetes to typical clinical manifestations, generally lasted about 10 years, and then experienced about 10 years into renal failure, and some deterioration of renal function in patients soon. Survey found that 30 percent of people with diabetes is the direct outcome of uremia diabetes. So how to prevent diabetic nephropathy it ?
First, adjust your diet
Diabetic nephropathy applied low-salt diet to reduce the edema and hypertension. As existing renal dysfunction, protein intake should be controlled not only beneficial for renal dysfunction, but also helps reduce urinary protein excretion. General daily protein intake of no more than 30 to 40 grams, should use high biological potency of protein, such as milk, eggs, meat, soy products should be limited.
Second, the long-term effective control of glucose metabolism
Glucose metabolism disorders affect capillary basement membrane, it changed the composition, thickening and permeability change occurs, causing diabetic nephropathy. Therefore, the active control of high blood sugar is a prerequisite for the prevention of diabetic nephropathy. For diabetic nephropathy have occurred with Gliquidon control blood sugar better. Severe cases of insulin to control blood sugar. Uremic patients, loss of appetite, eating less, even take the kidney itself reduced ability to inactivate insulin, insulin requirements decrease, easy hypoglycemia, should be ready to adjust the dose.
Third, prevention and treatment of urinary tract infections
Diabetes decreased resistance to infection, easily merge pyelonephritis, increased kidney damage. But without the typical clinical manifestations, no serious urinary frequency, urgency, dysuria, no fever, only mild discomfort urination and lower back pain. Urine culture can be diagnosed and treated with antibiotics.
Fourth, control of hypertension
Part of the diabetic patients with hypertension, high blood pressure can cause kidney damage, which in turn increased the blood pressure. Hypertensive patients with diabetes regardless of what causes should actively controlled. For the slow rate of decline in glomerular filtration rate is very important, blood pressure control is often also reduce urinary protein excretion. If the blood pressure in diabetic patients> 18.7 / 12kPa, we must actively take measures to 126/80 mm Hg drop in blood pressure, treatment of hypertension in this period is more important than the treatment of high blood sugar, but both want the same time. You can use calcium antagonists, such as: nifedipine, Norvasc, etc.; angiotensin converting enzyme inhibitors, such as: benazepril (Lotensin), fosinopril sodium tablets (Monopril), Cato captopril (Capoten), etc; edema were available indapamide (sodium reminders from). Blood pressure control in 18.7 / 11.3kPa (140 / 85mmHg) below.
Fifth, try to avoid nephrotoxic drugs and iodine contrast agent
Some drugs for kidney damage, should be avoided, such as: gentamicin, streptomycin, amikacin and so on. Iodinated contrast agents may also aggravate existing kidney damage, diabetes should avoid intravenous urography.
Sixth, improve renal microvascular disease
Given vasodilators, anti-platelet aggregation drugs and blood stasis drugs, such as alprostadil, Shuxuetong, dipyridamole, astragalus, Tan and so on.
Prevention and treatment of diabetic nephropathy is the key to early diagnosis and early intervention, regardless of whether people with impaired renal function in diabetic patients with early urinary albumin excretion rate detection is early detection and diagnosis of diabetic nephropathy in a better way, if detected results> 30mg / d or> 20ug / min, can be diagnosed as early diabetic nephropathy.
All patients with diabetes duration of more than five years, and they should always check kidney function, urine protein, 24-hour urinary protein excretion, and pay attention to blood pressure measurement, fundus examination. Conditions should do urine protein determination and β2- microglobulin, the early detection of diabetic nephropathy. If microalbuminuria increased within 3 to 6 months to even test three times to determine whether persistent microalbuminuria.
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